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ea0029p530 | Diabetes | ICEECE2012

Increased nuclear translocation of GAPDH in peripheral blood mononuclear cells (PBMCs) of diabetic patients.

Gougoura S. , Filliponi M. , Bargiota A. , Dritsa P. , Koukoulis G.

Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) not only functions as a central glycolytic enzyme but also is implicated in the process of apoptosis and gene transcription moving between the cytosol and nucleus. Oxidative stress modifies the activity of GAPDH.The aim of the study was to determine whether oxidative stress (OS) in diabetics is associated with induction of the apoptotic process and higher GAPDH translocation to the nucleus in PBMCs.<p ...

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ea0029p1390 | Pituitary Clinical | ICEECE2012

Oxidative stress and reduced anti-oxidative status, along with endothelial dysfunction in acromegaly

Anagnostis P. , Efstathiadou Z. , Gougoura S. , Polyzos S. , Karathanasi E. , Dritsa P. , Kita M. , Koukoulis G.

Introduction: Acromegaly is characterized by high cardiovascular morbidity and mortality. Oxidative stress and endothelial dysfunction are underlying mechanisms of atherosclerosis. The aim of this study was to evaluate the blood redox status and endothelial function by means of nitric oxide (NO) levels in patients with acromegaly.Description of methods/design: Total antioxidant capacity (TAC), catalase activity and glutathione concentration (GSH), as mea...

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Endocrine Abstracts

Increased nuclear translocation of GAPDH in peripheral blood mononuclear cells (PBMCs) of diabetic patients.

Oxidative stress and reduced anti-oxidative status, along with endothelial dysfunction in acromegaly

BiosciAbstracts